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JWH 210 is a potent cannabimimetic alkylindole, binding the central cannabinoid and peripheral cannabinoid receptors with Ki values of 0.46 and 0.69 nM, respectively.1 The effects of JWH 210 in whole cells or organisms have not been evaluated.

Stimulant
Stimulants excite the nervous system and increase physiological function.

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JWH-210 for sale, Its 10 grams is a potent cannabimimetic alkylindole, binding the central cannabinoid and peripheral cannabinoid receptors with Ki values of 0.46 and 0.69 nM, respectively. 1 The effects of JWH 210 in whole cells or organisms have not been evaluated.

Stimulant
Stimulants excite the nervous system and increase physiological function.
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JWH-210 Research Chemical

Research chemicals are drugs

Does Oral

Light               50-100mg
Common   100-200mg
Strong              200mg+

Duration         Oral Hours

Onset              Oral Minutes
After Effect      2-4 hours

More than 140 different synthetic cannabinoids (SC) have been identified in herbal mixtures consumed as recreational drugs. Knowledge of the acute toxicity of each individual compound remains sparse. Here we present a retrospective observational case series of patients presenting to emergency departments with the analytically confirmed intake as the only SC detected in serum samples. Cases were selected from a poison center database from March 2011 to June 2014. In total, 22 patients were included (aged 12-25 years, median 17.5; 18 males and 4 females). was identified in the serum samples in concentrations ranging from 0.18 to 90 ng/mL. Tachycardia, nausea, somnolence, hypokalemia, hypertension, restlessness, and/or agitation were most frequently reported. Diplopia, seizures, syncope, and ECG changes such as T-wave inversion and bradycardia were also noted.

Acute adverse effects of typically include central nervous system depression or cerebral seizures, but also signs of sympathomimetic toxicity. Nausea was reported in 80% and typically shows a sudden onset shortly after inhalation, suggesting a central nervous effect possibly mediated by CB1 receptors. Cardiovascular effects are reported in up to 80% of the patients and might not only include alterations in blood pressure and heart rate but also changes in the electrocardiogram (ECG).

 

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