PE-22-28

$55

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PE-22-28 is a synthetic derivative of the naturally occurring peptide spadin which binds to TREK-1.
TREK-1 is found in regions of the brain controlling mood, memory, and learning.
PE-22-28 is being researched for applications including antidepressant activity, learning, stroke recovery and neurodegenerative diseases such as Alzheimer’s.

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PE-22-28 nociceptin receptor agonist known for its potent and selective activation of the nociceptin/orphanin FQ peptide (NOP) receptor, a promising target in the development of non-opioid pain relief therapies. Unlike traditional opioids, PE-22-28 offers strong analgesic properties with reduced risks of dependence and respiratory depression, making it an attractive subject in neuropharmacology and preclinical pain management research.

PE-22-28 nociceptin receptor agonist

This compound is suitable for laboratory and research use only and is not approved for human consumption.

Explore our full range of NOP receptor ligands and browse other related compounds in our neuropharmacology research chemicals section.