Prednisone

Prednisone – Technical Information (Reference Only)

Chemical Information

• Synonyms:
  • Prednisone
  • Deltasone, Rayos, Sterapred (brand names)
  • 17,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione

• Formal Name:
  17,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione

• CAS Number:
  53-03-2

• Molecular Formula:
  C21H26O5

• Molecular Weight:
  358.43 g/mol

• Chemical Class:
  Corticosteroid; glucocorticoid

• Appearance:
  White to off-white crystalline powder

Structural / Spectral Information

• SMILES:
  C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=CC4(C3C(=O)C2(C1)C)C(=O)CO

• InChI:
  InChI=1S/C21H26O5/...

• InChI Key:
  OYPESQNJJNSDGD-UHFFFAOYSA-N

• λmax (UV):
  ~ 240 nm

Solubility

• Water: Slightly soluble

• Methanol / Ethanol: Soluble

• DMSO: Soluble

• Chloroform / Ether: Soluble

Formulation

• Supplied as Prednisone USP/EP grade

• Purity: ≥98% (analytical/research grade)

• Common pharmaceutical strengths:
  • 1 mg tablet
  • 2.5 mg tablet
  • 5 mg tablet
  • 10 mg tablet
  • 20 mg tablet
  • 50 mg tablet
  • Oral solution: 5 mg/5 mL

Storage & Stability

• Storage Temperature: 20–25 °C (room temperature)

• Shipping: Ambient temperature acceptable

• Stability: ≥3–5 years under recommended conditions

• Light/Moisture Sensitivity: Protect from prolonged exposure

Safety / Handling

• Avoid prolonged exposure to air and light for bulk powder

• Use PPE (gloves, mask) when handling

• Risk of immunosuppression and steroid-related side effects; follow dosing guidelines