Demerol (Meperidine HCL) 100mg/ml injection is a narcotic analgesic medication commonly administered for the treatment of light sedation and pain.
Acute Traumatic Encephalopathy with Elevated Intracranial Pressure:
In presence of head trauma, other intracranial lesions, or a preexisting surge in intracranial strain the, the respiratory depressant effects of meperidine, as well as its ability to raise cerebrospinal fluid pressure, can be markedly exaggerated. Meperidine also can increase the pressure in the cerebrospinal fluid. In addition, narcotics cause harmful effects, making, evaluating the clinical course of patients with brain traumas more challenging. Meperidine must be administered to these patients with considerable caution and only if its use is necessary.
Effects on Low Blood Pressure:
When administered to a postoperative patient or any individual whose capacity to maintain blood pressure has been compromised due to a depleted blood volume or the administration of drugs, including phenothiazines or positive anesthetics, meperidine can cause dangerously low blood pressure, also known as hypertension. This complication can also occur in patients who have not recently undergone surgery.
Utilization in Patients Capable of Walking:
Meperidine can impair a person’s intellectual and/or physical capacities, which are necessary for performing potentially dangerous tasks such as operating heavy machinery or driving a car. Therefore, the affected person ought to be recommended.
Meperidine, much like other opioids, has the potential to cause orthostatic hypotension in ambulatory patients.
Application During Pregnancy:
Because safe use in pregnancy before labor has not been established, meperidine must not be used in pregnant women before the duration of labor unless, in the doctor’s judgment, the potential benefits outweigh the potential risks. This is because safe use in pregnancy before labor has not been established relative to the possibility of adverse effects on fetal development.
Interactions with other depressants of the central nervous system
DEMEROL should be used with caution, and patients who are simultaneously receiving other central nervous system depressants, such as sedatives or hypnotics, common anesthetics, phenothiazines, other tranquilizers, and alcohol, should begin with a reduced dosage. Attention must be paid to taking delivery of starting with a reduced dosage. If such tablets are combined with regular doses of DEMEROL, drug-drug interactions may also result in respiratory failure, hypotension, extreme drowsiness, or coma. These adverse effects may also be caused by DEMEROL alone.
Due to the possibility of vagolytic activity, meperidine should be taken with extreme caution in patients who suffer from atrial flutter and other types of supraventricular tachycardia. This is because vagolytic activity can lead to a significant increase in the ventricular reaction rate.