Tramadol (Ultram)

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Tramadol (Ultram) is often considered a “step” between non-opioid relievers (like Ibuprofen) and stronger narcotics (like Morphine). It is converted in the liver by the CYP2D6 enzyme into a much more potent metabolite ( $M_1$ ). Because it increases serotonin levels, it must be used with extreme caution in patients taking antidepressants to avoid Serotonin Syndrome. It is also uniquely associated with a risk of seizures, even at recommended doses, particularly in those with a history of epilepsy or those taking certain other medications.

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Description
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Tramadol – Technical Information (Reference Only)

Chemical Information

Synonyms:
• Tramadol hydrochloride
• Ultram, ConZip, Ryzolt (brand names)
• (1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride
Formal Name:
(1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride
CAS Number:
27203-92-5
Molecular Formula:
C16H25NO2 · HCl
Molecular Weight:
263.8 g/mol
Chemical Class:
Opioid analgesic; centrally acting synthetic opioid
Appearance:
White crystalline powder

Structural / Spectral Information

SMILES:
COC1=CC=CC=C1[C@H]2C[C@@H](CC[C@H]2CN(C)C)O
InChI:
InChI=1S/C16H25NO2.HCl/...
InChI Key:
NWXJXEDCBPQWRX-UHFFFAOYSA-M
λmax (UV):
~ 271 nm

Solubility

Water: Freely soluble (as hydrochloride salt)
Methanol / Ethanol: Soluble
DMSO: Soluble
Chloroform / Ether: Slightly soluble

Formulation

Supplied as Tramadol hydrochloride USP/EP grade
Purity: ≥98% (analytical/research grade)
Common pharmaceutical strengths:
• 50 mg tablet / capsule
• 100 mg tablet (extended-release)
• 150 mg extended-release tablet
• 200 mg extended-release tablet
• 300 mg extended-release tablet
• Oral solution: 10 mg/mL