Tramadol (Ultram)

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Tramadol (Ultram) is often considered a “step” between non-opioid relievers (like Ibuprofen) and stronger narcotics (like Morphine). It is converted in the liver by the CYP2D6 enzyme into a much more potent metabolite ($M_1$). Because it increases serotonin levels, it must be used with extreme caution in patients taking antidepressants to avoid Serotonin Syndrome. It is also uniquely associated with a risk of seizures, even at recommended doses, particularly in those with a history of epilepsy or those taking certain other medications.

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Tramadol – Technical Information (Reference Only)

Chemical Information

  • Synonyms:
    • Tramadol hydrochloride
    • Ultram, ConZip, Ryzolt (brand names)
    • (1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride

  • Formal Name:
    (1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride

  • CAS Number:
    27203-92-5

  • Molecular Formula:
    C16H25NO2 · HCl

  • Molecular Weight:
    263.8 g/mol

  • Chemical Class:
    Opioid analgesic; centrally acting synthetic opioid

  • Appearance:
    White crystalline powder

Structural / Spectral Information

  • SMILES:
    COC1=CC=CC=C1[C@H]2C[C@@H](CC[C@H]2CN(C)C)O

  • InChI:
    InChI=1S/C16H25NO2.HCl/...

  • InChI Key:
    NWXJXEDCBPQWRX-UHFFFAOYSA-M

  • λmax (UV):
    ~ 271 nm

Solubility

  • Water: Freely soluble (as hydrochloride salt)

  • Methanol / Ethanol: Soluble

  • DMSO: Soluble

  • Chloroform / Ether: Slightly soluble

Formulation

  • Supplied as Tramadol hydrochloride USP/EP grade

  • Purity: ≥98% (analytical/research grade)

  • Common pharmaceutical strengths:
    • 50 mg tablet / capsule
    • 100 mg tablet (extended-release)
    • 150 mg extended-release tablet
    • 200 mg extended-release tablet
    • 300 mg extended-release tablet
    • Oral solution: 10 mg/mL

Storage & Stability

  • Storage Temperature: 20–25 °C (room temperature)

  • Shipping: Ambient temperature acceptable

  • Stability: ≥3–5 years if stored dry and protected from light

  • Light/Moisture Sensitivity: Protect from prolonged exposure

Safety / Handling

  • Controlled substance (risk of dependence and abuse)

  • Avoid inhalation of powder

  • Use PPE when handling bulk material

  • Store in sealed, dry containers, away from unauthorized access

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