Ibrance 125 mg

Product Information:

Ibrance is the brand name for palbociclib, a CDK4/6 inhibitor. It works by blocking proteins called CDK4 and CDK6, which cancer cells need to divide and grow. By inhibiting these proteins, Ibrance slows down cancer growth.

Uses:

• HR-positive (hormone receptor-positive) and HER2-negative advanced or metastatic breast cancer in combination with hormone therapy (like letrozole or fulvestrant).

How to Take Ibrance:

• Form: Oral capsules.

• Typical dose: Usually 125 mg once daily for 21 consecutive days, followed by 7 days off (28-day cycle). Dose may be adjusted based on side effects.

• With food: Take with or without food, preferably at the same time each day.

• Important: Swallow capsules whole. Do not crush, chew, or open them.

• Monitoring: Your doctor will check your blood counts regularly because Ibrance can lower white blood cells.

Warnings:

1. Blood cell problems: Can cause low neutrophils (risk of infection), anemia, or low platelets.

2. Liver problems: Monitor liver function; dosage may need adjustment if liver enzymes rise.

3. Lung problems: Rarely, can cause interstitial lung disease or pneumonitis.

4. Pregnancy/Breastfeeding: Can harm a fetus. Use effective contraception and avoid breastfeeding.

5. Drug interactions: Avoid strong CYP3A inhibitors or inducers (like certain antifungals, antibiotics, or anticonvulsants) unless your doctor adjusts your dose.

Side Effects:

• Very common:

  • Low white blood cells (neutropenia)

  • Fatigue

  • Nausea

  • Hair thinning (alopecia)

  • Mouth sores

  • Diarrhea

  • Infections

• Serious but less common:

  • Severe neutropenia (infection risk)

  • Lung inflammation

  • Liver damage

  • Allergic reactions