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Amoxicillin – Technical Information (Reference Only)

Chemical Information

• Synonyms:
  • Amoxicillin trihydrate
  • 6-[D(-)-α-Amino-p-hydroxyphenylacetamido]penicillanic acid trihydrate
  • Amoxil, Moxatag (brand names)

• Formal Name:
  (2S,5R,6R)-6-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate

• CAS Number:
  61336-70-7

• Molecular Formula:
  C16H19N3O5S·3H2O

• Molecular Weight:
  365.4 g/mol (anhydrous), ~399.4 g/mol (trihydrate)

• Chemical Class:
  Beta-lactam antibiotic (penicillin derivative)

• Appearance:
  White to off-white crystalline powder

Structural / Spectral Information

• SMILES:
  CC1(C)S[C@@H]2[C@H](NC(=O)[C@@H](C(=O)O)NCC3=CC=C(C=C3)O)C(=O)N2C1=O

• InChI:
  InChI=1S/C16H19N3O5S/...

• InChI Key:
  XZGIZRKMDDVBTU-ZSDSKKNJSA-N

• λmax (UV):
  ~ 230–270 nm (varies with solvent)

Solubility

• Water: Freely soluble

• Methanol / Ethanol: Slightly soluble

• DMSO: Soluble

• Chloroform / Ether: Insoluble

Formulation

• Supplied as Amoxicillin USP/EP grade

• Purity: ≥98% (analytical/research grade)

• Common pharmaceutical strengths:
  • 125 mg (oral suspension)
  • 250 mg capsules/tablets
  • 500 mg capsules/tablets
  • 875 mg tablets/capsules
  • 400 mg/5 mL oral suspension (for pediatrics)

Storage & Stability

• Storage Temperature: 2–8 °C recommended for suspensions; tablets/capsules stable at room temperature

• Shipping: Ambient temperature acceptable

• Stability: ≥3–5 years under proper storage

• Light/Moisture Sensitivity: Protect from prolonged exposure; store in dry containers

Safety / Handling

• Low acute toxicity

• Avoid inhalation of powder

• Use PPE (gloves, mask) when handling bulk material

• Sensitive to moisture; keep in sealed container