Metoprolol

Metoprolol Tartrate / Succinate – Technical Information (Reference Only)

Chemical Information

• Synonyms:
  • Metoprolol tartrate
  • Metoprolol succinate (extended-release)
  • Lopressor, Toprol-XL (brand names)

• Formal Name:
  (RS)-1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol tartrate / succinate

• CAS Numbers:
  • Metoprolol tartrate: 37350-58-6
  • Metoprolol succinate: 37350-59-7

• Molecular Formula:
  • Tartrate: C15H25NO3·C4H6O6
  • Succinate: C15H25NO3·C4H6O4

• Molecular Weight:
  • Tartrate: ~ 684.8 g/mol
  • Succinate: ~ 492.6 g/mol

• Chemical Class:
  Beta-1 selective adrenergic receptor blocker (beta-blocker)

• Appearance:
  White crystalline powder

Structural / Spectral Information

• SMILES (tartrate):
  CC(C)NCC(COC1=CC=C(C=C1)OCC)O.C(C(C(=O)O)O)C(=O)O

• InChI (tartrate):
  InChI=1S/C15H25NO3.C4H6O6/...

• InChI Key (tartrate):
  NSVYRLHTSGFPGS-UHFFFAOYSA-N

• λmax (UV):
  ~ 275 nm (varies by solvent)

Solubility

• Water: Freely soluble (tartrate and succinate)

• Methanol / Ethanol: Soluble

• DMSO: Soluble

• Chloroform / Ether: Practically insoluble

Formulation

• Supplied as Metoprolol tartrate or succinate USP/EP grade

• Purity: ≥98% (research/analytical grade)

• Common pharmaceutical tablet strengths:
  • Immediate release (tartrate): 25 mg, 50 mg, 100 mg
  • Extended release (succinate): 25 mg, 50 mg, 100 mg, 200 mg

Storage & Stability

• Storage Temperature: 20–25 °C (room temperature)

• Shipping: Ambient temperature acceptable

• Stability: ≥3–5 years when stored dry and protected from light

Safety / Handling

• Low acute toxicity

• Avoid inhalation of powder

• Use PPE (gloves, mask) when handling bulk material

• Protect from moisture