Stelara

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Stelara (ustekinumab) is a biologic injection for autoimmune conditions like psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis. It reduces inflammation by blocking IL-12 and IL-23. Common side effects include infections, headaches, fatigue, and injection site reactions. Regular monitoring and infection screening are essential for safe use.

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Product Information:

Stelara is a biologic medication used to treat certain autoimmune conditions by targeting interleukins IL-12 and IL-23, which are proteins that cause inflammation. By blocking these proteins, Stelara reduces overactive immune responses.

Uses:

  • Plaque psoriasis (moderate to severe)

  • Psoriatic arthritis

  • Crohn’s disease

  • Ulcerative colitis

How to Take Stelara:

  • Form: Injectable (subcutaneous) or intravenous (IV) depending on the condition.

  • Dosing (subcutaneous for psoriasis):

    • Weight-based dose for first injection at week 0, second at week 4, then every 12 weeks.

    • For Crohn’s or ulcerative colitis, IV induction is usually given at weeks 0 and 8, then subcutaneous maintenance every 8 or 12 weeks.

  • Administration:

    • Subcutaneous injections are usually done in the thigh, abdomen, or upper arm.

    • Can be self-administered at home after training.

  • Monitoring: Your doctor may check blood tests and screen for infections before starting treatment.

Warnings:

  1. Infections: Can increase risk of serious infections (tuberculosis, bacterial infections, fungal infections). Screen for TB before starting.

  2. Cancer risk: Long-term immune suppression may slightly increase risk of certain cancers.

  3. Allergic reactions: Rare but possible during or after injection.

  4. Vaccines: Avoid live vaccines during treatment.

  5. Pregnancy/Breastfeeding: Use only if clearly needed; discuss with your doctor.

Side Effects:

  • Upper respiratory infections (cold, sinus infections)

  • Headache

  • Fatigue

  • Injection site reactions (redness, pain, swelling)

  • Nausea

  • Diarrhea

Serious but rare:

  • Severe infections

  • Allergic reactions

  • Liver problems

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